FADZ PHARMA INC

The lipid modifying effects of fenofibrate are mediated by the activation of peroxisome proliferator activated receptor type alpha (PPARα). Through this mechanism, fenofibrate increases lipolysis and elimination of atherogenic triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III (an inhibitor of lipoprotein lipase activity). The reduction in triglyceride concentrations alters the size and composition of LDL-cholesterol from small, dense particles to larger, more buoyant particles that are less atherogenic and more rapidly catabolized. PPARα activation also induces an increase in the synthesis of apo A-I, A-II, and HDL-cholesterol.

Fenofibric acid decreases total cholesterol (total-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein B (apo B), very low density lipoprotein cholesterol (VLDL-C), and triglycerides. In addition, fenofibric acid increases high density lipoprotein cholesterol (HDL-C), apolipoproteins A-I and A-II.

Fenofibrate has been shown to reduce serum uric acid concentrations in healthy and hyperuricemic individuals by increasing the urinary excretion of uric acid.