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Cefuroxime Sodium
750 mg (vial with diluent)
Quiroxef 750
Antibacterial (I.M./ I.V.)
Formulation
Each vial contains:
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Cefuroxime (as sodium) USP – 750mg
Mechanism of Action
Cefuroxime inhibits bacterial cell wall synthesis following attachment to penicillin-binding proteins (PBPs). This result in the interruption of cell wall (peptidoglycan) biosynthesis, which leads to bacterial cellysis and death.
Indication
Used in the treatment of susceptible infections such as bone and joint infections, bronchitis (and other lower respiratory tract infections), gonorrhea, meningitis (although treatment failures have been reported in H. influenzae meningitis), otitis media, peritonitis, pharyngitis, sinusitis, skin infection (including soft-tissue infections, and UTI. It also used for surgical infection prophylaxis.
Dosaging
Cefuroxime may be administered intravenously or intramuscularly.
Adults: The usual dose Cefuroxime is 750mg three times daily by I.M. or I.V. injection which may be increased to 1.5g three times daily I.V. in severe infections. The frequency of administration can be increased to six-hourly if necessary, giving total doses of 3g to 6g daily.
Infants and children: 30 to 60 mg/kg/day increases to 100 mg/kg daily, if necessary, given as three or four divided doses. A dose of 60 mg/kg/day will be appropriate for most infections.
Elderly: As prescribed by the physician
Dosage in Impaired Renal Function: As Cefuroxime is excreted by the kidneys, the dosage of the Cefuroxime should be reduced in patients with creatinine clearance below 20ml/min, 750mg twice daily is recommended and with 10 ml/min, 750mg once daily is adequate. For patients on hemodialysis, a further 750mg dose should be given at the end of each dialysis. In case of continuous peritoneal dialysis, 750mg twice daily is recommended.
Availability
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750 mg (vial with diluent)
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Box of 20ml USP Type III clear glass vial + glass ampoule x 10ml diluent
Pregnancy & Lactation
As there are no well-controlled clinical trials of Cefuroxime in pregnant woman, it should be administered only if necessary and with caution. Cefuroxime is excreted in human milk, and consequently, caution should be exercised when Cefuroxime is administered to a nursing mother.
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