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Cefuroxime Axetil

Quiroxef 500

500 mg Film-Coated Tablet

Antibacterial (Cephalosporin)

Formulation

Each film-coated tablet contains:
Cefuroxime Axetil eq. to Cefuroxime - 500 mg

Mechanism of Action

Cefuroxime axetil owes its in vivo bactericidal activity to the parent compound Cefuroxime. Cefuroxime is a well characterized and effective antibacterial agent which has bactericidal activity against a wide range of common pathogens, including -lactamase producing strains. Cefuroxime has good stability to bacterial. - lactamase, and consequently is active against many ampicillin-resistant or amoxicillin-resistant strains. The bactericidal action of Cefuroxime results from inhibition of cell wall synthesis by binding to essential target proteins.

Indication

For the treatment of susceptible infections. Cefuroxime is used in bone and joint infections, bronchitis (and other lower respiratory tract infections), gonorrhea, meningitis (although treatment failures have been reported in H. influenzae meningitis), otitis media, peritonitis, pharyngitis, sinusitis, skin infections (including soft tissue infections), and urinary tract infections. It is also used for surgical infection prophylaxis

Dosaging

For Uncomplicated Urinary Tract Infections: 125 mg twice daily.

For Respiratory Tract Infections: 250 to 500 mg twice daily.

A dose for children more than 3 months of age: 125 mg twice daily or 10 mg/kg twice daily to a maximum of 250 mg daily.

Children over 2 years of age with otitis media: 250 mg twice daily or 15 mg/kg twice daily to a maximum of 500 mg daily.

Adults with Pneumonia or with Acute Exacerbations of Chronic Bronchitis: 1.5 g twice daily or 750 mg twice daily, respectively, in parenteral route followed by oral Cefuroxime 500 mg twice daily in each case.

For Lyme disease in adults: 500 mg is given twice daily for 20 days.

For Uncomplicated Gonorrhea: A single 1g oral dose of Cefuroxime can be given

Availability

  • Alu / Alu Blister

  • Pack of 10’s (Box of 10’s, 50’s & 100’s)

Pregnancy & Lactation

Cefuroxime Axetil should be administered with caution during the early months of pregnancy. This drug should be used during pregnancy only if clearly needed.

Lactation: Cefuroxime is excreted in human milk, and consequently caution should be exercised when Cefuroxime axetil is administered to a nursing mother.

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